Endocrine Abstracts

The ability of local invasion and distant metastasis indicates malignancy. Focal adhesion complex plays an important role during cell invasion. This complex consists of integrins, focal adhesion kinase (FAK), vinculin, talin, α-actinin and paxillin. Activation of FAK regulates the assembly of focal adhesion and stress fiber formation via GTPase Rho and Rac, which is responsible for the migratory behavior of cells. In this study, we demonstrated the inhibitory effect of ro...

Context: Total pancreatectomy (TP) with islet cell autotransplantation (IAT) can reduce or prevent diabetes by preserving β-cell function, and is normally performed with on-site isolation laboratory facilities.Objective: We examined factors associated with islet yield and metabolic outcomes in patients with chronic pancreatitis undergoing TP-IAT. We report our experience of TP-IAT with an off-site islet isolation laboratory.Pa...